Microsoft Edge displays "Open this file" or "Report file as unsafe" pop-up when editing a document
Issue
When opening a document for editing, the Microsoft Edge browser displays a pop-up warning about the file, either:
"Open this file"
"Report file as unsafe?"
Clicking the "Open" button, Edge will open a new tab and display the same pop-up in a loop.
Cause:
This is caused by Microsoft Defender Smartscreen, designed to protect against phishing or malware websites and applications, and the downloading of potentially malicious files.
Solution:
Contact your IT team to review the Microsoft Defender Smartscreen settings, and update as required to resolve the issue.